Autoimmune hepatitis is liver inflammation that occurs when your body’s immune system turns against liver cells. The exact cause of autoimmune hepatitis is unclear, but genetic and environmental factors appear to interact over time in triggering the disease.
Untreated autoimmune hepatitis can lead to scarring of the liver (cirrhosis) and eventually to liver failure. When diagnosed and treated early, however, autoimmune hepatitis often can be controlled with drugs that suppress the immune system.
A liver transplant may be an option when autoimmune hepatitis doesn’t respond to drug treatments or when liver disease is advanced.
Symptoms
Signs and symptoms of autoimmune hepatitis can range from minor to severe and may come on suddenly. Some people have few, if any, recognized problems in the early stages of the disease, whereas others experience signs and symptoms that may include:
- Fatigue
- Abdominal discomfort
- Yellowing of the skin and whites of the eyes (jaundice)
- An enlarged liver
- Abnormal blood vessels on the skin (spider angiomas)
- Skin rashes
- Joint pains
- In women, loss of menstruation
Causes
Autoimmune hepatitis occurs when the body’s immune system, which ordinarily attacks viruses, bacteria and other pathogens, instead targets the liver. This attack on your liver can lead to chronic inflammation and serious damage to liver cells. Just why the body turns against itself is unclear, but researchers think autoimmune hepatitis could be caused by the interaction of genes controlling immune-system function and exposure to particular viruses or drugs.
Types of autoimmune hepatitis
Doctors have identified two main forms of autoimmune hepatitis:
- Type 1 autoimmune hepatitis.This is the most common type of the disease. It can occur at any age. About half the people with type 1 autoimmune hepatitis have other autoimmune disorders, such as celiac disease, rheumatoid arthritis or ulcerative colitis.
- Type 2 autoimmune hepatitis.Although adults can develop type 2 autoimmune hepatitis, it’s most common in children and young people. Other autoimmune diseases may also accompany this type of autoimmune hepatitis.
Factors that may increase your risk of autoimmune hepatitis include:
- Being female.Although both men and women can develop autoimmune hepatitis, the disease is more common in women.
- A history of certain infections.Autoimmune hepatitis may develop after you’re infected with the measles, herpes simplex or Epstein-Barr virus. The disease is also linked to hepatitis A, B or C infection.
- Evidence suggests that a predisposition to autoimmune hepatitis may run in families.
- Having an autoimmune disease.People who already have an autoimmune disease, such as celiac disease, rheumatoid arthritis or hyperthyroidism (Graves’ disease or Hashimoto’s thyroiditis), may be more likely to develop autoimmune hepatitis.
- Esophageal varices
Autoimmune hepatitis that goes untreated can cause permanent scarring of the liver tissue (cirrhosis). Complications of cirrhosis include:
- Enlarged veins in your esophagus (esophageal varices).When circulation through the portal vein is blocked, blood may back up into other blood vessels — mainly those in your stomach and esophagus. The blood vessels are thin walled, and because they’re filled with more blood than they’re meant to carry, they’re likely to bleed. Massive bleeding in the esophagus or stomach from these blood vessels is a life-threatening emergency that requires immediate medical care.
- Fluid in your abdomen (ascites).Liver disease can cause large amounts of fluid to accumulate in your abdomen. Ascites can be uncomfortable and may interfere with breathing and is usually a sign of advanced cirrhosis.
- Liver failure.This occurs when extensive damage to liver cells makes it impossible for your liver to function adequately. At this point, a liver transplant is needed.
- Liver cancer.People with cirrhosis have an increased risk of liver cancer.
Autoimmune Disease are the one which is giving by your own immunity.Immunity is meant to protect you from outside diseases,but here they are’nt protecting you.Each and every cell of your body is govern by your min but and when you damage yourself by your nature then your immunity starts damaging you.So to cure autoimmune disease you have till the time you don’t make adequate change in your nature of harming your own self your auto immunity will not go.
Rheumatoid arthritis is a chronic inflammatory disorder that can affect more than just your joints. In some people, the condition also can damage a wide variety of body systems, including the skin, eyes, lungs, heart and blood vessels.
An autoimmune disorder, rheumatoid arthritis occurs when your immune system mistakenly attacks your own body’s tissues.
Unlike the wear-and-tear damage of osteoarthritis, rheumatoid arthritis affects the lining of your joints, causing a painful swelling that can eventually result in bone erosion and joint deformity.
The inflammation associated with rheumatoid arthritis is what can damage other parts of the body as well. While new types of medications have improved treatment options dramatically, severe rheumatoid arthritis can still cause physical disabilities.
Psoriasis is a common skin condition that speeds up the life cycle of skin cells. It causes cells to build up rapidly on the surface of the skin. The extra skin cells form scales and red patches that are itchy and sometimes painful.
Psoriasis is a chronic disease that often comes and goes. The main goal of treatment is to stop the skin cells from growing so quickly.
There is no cure for psoriasis, but you can manage symptoms. Lifestyle measures, such as moisturizing, quitting smoking and managing stress, may help.
Ankylosing spondylitis is an inflammatory disease that, over time, can cause some of the vertebrae in your spine to fuse. This fusing makes the spine less flexible and can result in a hunched-forward posture. If ribs are affected, it can be difficult to breathe deeply.
Ankylosing spondylitis affects men more often than women. Signs and symptoms typically begin in early adulthood. Inflammation also can occur in other parts of your body — most commonly, your eyes.
There is no cure for ankylosing spondylitis, but treatments can lessen your symptoms and possibly slow progression of the disease.
